Paraoxonase and arylesterase levels in autoimmune thyroid diseases
نویسندگان
چکیده
منابع مشابه
PARAOXONASE AND ARYLESTERASE ACTIVITY AMONG HYPERCHOLESTEROLEMIC PATIENTS
Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We exa...
متن کاملParaoxonase and arylesterase activity in bladder cancer.
OBJECTIVE Oxidative stress is the main pathogenetic mechanism in bladder cancer among many other causes. We aimed to investigate whether a potential relationship exists between bladder cancer and the activities of paraoxonase (PON1) and arylesterase (ARE) enzymes. MATERIAL AND METHODS The study included 56 patients with bladder cancer, and 57 healthy individuals. The relationships between enz...
متن کاملParaoxonase and Arylesterase Activities in Patients with Cancer
Background: Cancer has the highest disease-related mortality rate in Iran. Reduced activity of paraoxonase reported in patients with cancer may be due to a reduction in its antioxidant properties and a subsequent increased risk of developing cancer. We aimed to assess antioxidant and oxidative status in patients with cancer through measuring the activity of PON1 as an antioxidant enzyme and det...
متن کاملStudies on human serum paraoxonase/arylesterase.
The complete amino acid sequence of human serum paraoxonase/arylesterase and the DNA sequence coding for that protein have recently been determined in two independent laboratories. There is now considerable evidence that the esterase exists in two genetically determined allozymic forms, and these A and B allozymes possess both paraoxonase and arylesterase activities. The B-type esterase has rel...
متن کاملEpigenetics and Autoimmune Thyroid Diseases
Increasing evidence suggests that epigenetic modifications, including changes in DNA methylation, covalent modifications of histone tails, and gene silencing mediated by non-coding RNA molecules, play a substantial role in the pathogenesis of autoimmune disorders and might be seen as the result of environmental insults that trigger these conditions. Studies in cells and tissues of patients with...
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ژورنال
عنوان ژورنال: Redox Report
سال: 2016
ISSN: 1351-0002,1743-2928
DOI: 10.1080/13510002.2015.1107310